Each Capsule Contains:
Grape Seed Extract (80:1)
Vitis vinifera |
|
Grape Skin Extract (48:1)
Vitis vinifera |
77.50 mg |
Quercetin Dihydrate |
5.00 mg |
Grape Leaf Extract (10:1)
Vitis vinifera |
5.00 mg |
Non-medicinal ingredients: microcrystalline cellulose, magnesium stearate, colloidal silicon dioxide, vegetarian capsules. |
Avoid use during pregnancy and nursing.
|
|
References
1. Stein, Rob. Is substance in red wine the secret to long life? The Seattle Times. Thursday, November 2, 2006.
http://seattletimes.nwsource.com/html/nationworld/2003336876_wine02.html
2. Shi J, Yu J, Pohorly JE, Kakuda Y. Polyphenolics in grape seeds–biochemistry and functionality. J Med Food. 2003 Winter;6(4):291-9. Arita, T. The antioxidative function, preventive action on disease and utilization of proanthocyanidins. Biofactors. 2004;21(1-4):197-201.
3. Wade, Nicholas.Red Wine Ingredient Increases Endurance, Study Shows. New York Times. November 16, 2006
4.British Heart Foundation web site. Tab 3.5 RSD web08: Age-standardised rate of finished consultant episodes for operations for CHD by sex and local authority, all ages and under 75 years, 2001/06, England (Table) http://www.heartstats.org/atozpage.asp?id=5105
5. World Health Organization. Global Database on Body Mass Index. http://www.who.int/bmi/index.jsp
6. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ra maswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA. Resveratrol improves health and survival of mice on a high-calorie diet Nature 2006 advanced publication.
7. Lagouge M, Argmann C, Gerhart-Hines Z, et al (2006). Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha" Cell 127 (6): 1109–22.
8. Walle, Thomas; Hsieh, Faye; DeLegge, Mark H.; Oatis, Jr., John E.; and Walle, U. Kristina U. Kristina. High absorption but very low bioavailability of oral resveratrol in humans. Drug metabolism and disposition: the biological fate of chemicals. 2004 Dec;32(12):1377-82.
9. Clifton, Peter M. Effect of Grape Seed Extract and Quercetin on Cardiovascular and Endothelial Parameters in High-Risk Subjects. Journal of Biomedicine and Biotechnology. 2004:5 (2004) 272-278. Sano, Atsushi et al. Procyanidin B1 is Detected in Human Serum after Intake of Proanthocyanidin-rich Grape Seed Extract. Bioscience, Biotechnology, Biochemistry., 67 (5), 1140-1143, 2003. Bagchi, D. et al. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology. 2000 Aug 7;148
(2-3):187-97. Bratman, S.; Girman, A. Mosby's Handbook of Herbs and Supplements and Their Therapeutic Uses. Mosby, Inc., Missouri, 2003: 772-7; 841-843. Natural Standard Monograph: Quercetin [internet] 2006. Cited 8/21/2006.
10. Devi, A.; Jolitha, AB.; Ishii, N. Grape seed proanthocyanidin extract (GSPE) and antioxidant defense in the brain of adult rats. Med Sci Monit. 2006 Apr;12(4)BR124-9.
11. Wang, J.; Ho, L.; Zhao, Wei; et al. Grape-Derived Polyphenolics Prevent Aβ Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease. The Journal of Neuroscience, June 18, 2008, 28(25):6388-6392.
12. Costantini A, De Bernardi T, Gotti A. Clinical and capillaroscopic evaluation of chronic uncomplicated venous insufficiency with procyanidins extracted from vitis vinifera. Minerva Car dioangiol 1999 Jan-Feb;47(1-2):39-46.system of aged rats by grape seed extract. Neurosci Lett. 2005 Aug 5;383(3):295-300.
13. Balu, M; Sangeetha, P; Haripriya, D; Panneerselvam, C. Rejuvenation of antioxidant system in central nervous system of aged rats by grape seed extract. Neurosci Lett. 2005 Aug 5;383(3):295-300.
14. Health Canada Natural Health Product Monograph. Vitamin C. September 14, 2007.
15. Arita, T. The antioxidative function, preventive action on disease and utilization of proanthocyanidins. Biofactors. 2004;21(1-4):197-201. Bagchi, D. et al. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology. 2000 Aug 7;148(2-3):187-97. Shi, J.; Yu, J.; Pohorly, JE.; Kakuda, Y. Polyphenolics in grape seeds—biochemistry and functionality. J Med Food. 2003 Winter;6(4);291-9. Sreemantula, S.; Nammi, S.; Kolanuukonda, R.; Koppula, S.; Boini, Km. Adaptogenic and nootropic activities of aqueous extract of Vitis vinifera (grape seed): an experimental study in rat model. BMC Complement Altern Med. 2005 Jan 19;5(1):1.
16. OPCs appear to be nontoxic and are generally well tolerated. Grape seeds OPCs are better studied than OPCs extracted from maritime pine bark. Bratman, S.; Girman, A. Mosby's Handbook of Herbs and Supplements and Their Therapeutic Uses. Mosby, Inc., Missouri, 2003: 772-7; 841-843.
17. Always read and follow the directions on the package. Consult your health care professional before taking this or any supplement. Avoid use during pregnancy and nursing.
18. Nordestgaard, B.G.; Benn, M.; Schnohr, P.; Tybjærg-Hansen, A. Nonfasting Triglycerides and Risk of Myocardial Infarction, Ischemic Heart Disease, and Death in Men and Women. JAMA. 2007;298:299-308.
19. Shi, J.; Yu, J.; Pohorly, JE.; Kakuda, Y. Polyphenolics in grape seeds—biochemistry and functionality. J Med Food. 2003 Winter;6(4);291-9. Arita, T. The antioxidative function,
preventive action on disease and utilization of proanthocyanidins. Biofactors. 2004;21(1-4):197-201. Zern, Tosca L. and Maria Luz Fernandez. Cardioprotective Effects of Dietary Polyphenols. Journal of Nutrition 135: 2291-2294, 2005.
20. Whitney, Craig R. Jeanne Calment, World's Elder, Dies at 122, New York Times. August 5, 1997. The Guinness Book of Records, 1999 edition, p.102. Believed to be world's oldest, woman in France dies at 122, Houston Chronicle, August 4, 1997. Totheroh, G. Uncovering a Key to Human Longevity. The Christian Broadcasting Network. http://www.cbn.com/CBNNews/News/040106a.aspx
21. Natural Standard Monograph: Quercetin [internet] 2006. Cited 8/21/2006.
22. Paliwal, S.; Sundaram, J.; and Mitragotri, S. Induction of cancer-specific cytotoxicity towards human prostate and skin cells using quercetin and ultrasound. British Journal of Cancer (2005) 92, 499-502.
© Copyright 2009. The information contained herein is not to be construed as medical advice or instruction. On any matter relating to your health or well-being, please check with an appropriate health professional. Information herein, while believed to be correct by the author, is not guaranteed as accurate or appropriate for all persons. No statement herein is to be construed as a diagnosis, treatment, preventive, or cure for any disease, disorder, or abnormal physical state. Statements herein have not been evaluated by the Food and Drug Administration. Dr. Victor Marchione is compensated by Bel Marra Nutritionals for his work in formulating and endorsing this product.
|
|